Main ContentSirtuin Signaling in Cardiac Metabolism Image Long Description
Overview
Distinct subcellular distribution and interaction of SIRT1 and SIRT3 with cardiac aging under physiological and pathological conditions. Immunofluorescence staining show the translocation of cardiomyocyte SIRT1 from nucleus to cytoplasm in response to pathological stress. The immunogold double labeling of SIRT1 and SIRT3 in the nucleus of the left ventricular area at risk of young and aged hearts. The representative immunogold labeling images of SIRT1 (labeled with small size dots) and SIRT3 (labeled with big size dots) in young and aged hearts. The distribution of nuclear SIRT1 and SIRT3 gold particles and distribution of mitochondrial SIRT1 and SIRT3 gold particles in the heart’s left ventricular area at risk.
Presentation
There are six panels (three rows of two) showing imaging results for cardiac muscle cells called cardiomyocytes.
The top row has panels with black backgrounds and red striations (Troponin T). Overlaid on the red striations are green (SIRT1) and blue (DAPI) oblong shapes. The left box is labeled Sham, and the second box is labeled Ox stress. At the bottom of each box is the label 20 μm with a line under it and a white square outline on the bottom right corner.
The bottom two rows have oblong shapes in various shades of gray and black dots throughout. A gray outline of a heart illustration overlays all four squares. The squares are labeled as follows along the top:
Top left: Nucleus, Young
Top right: Nucleus, Aged
Bottom left: Mitochondria, Young
Bottom right: Mitochondria, Aged
On the top left of each square is a legend for the black dots: small dots for SIRT1 and large dots for SIRT3.
On the bottom left of each square is the text 200 nm with a black line under it.
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